In 1982, Merck Frosst Canada was created through the retsructuring of Merck & Co., Charles E. Frosst, and Merck Sharp & Dohme Canada Limited to become a fully integrated pharmaceutical company. The company later changed its name to Merck Frosst Canada Ltd.

Charles E. Frosst & Co, was founded by Mr. Frosst and four associates In 1899 who rapidly introduced new products such as the famous numbered analgesics known as 217ﾮ and 222ﾮ ﾗ products that are still used in Canada.

During the mid-forties, Charles Frosst pioneered nuclear medicine in Canada by developing the country’s first radioactive pharmaceutical products, for sale in Canada and abroad. In 1965, Merck & Co. of New Jersey acquired Charles E. Frosst.