On Jul. 12, 1960, President Dwight D. Eisenhower approved the Federal Hazardous Substances Labeling Act (FHSA), enforced by U.S. Food and Drug Administration (FDA), which required prominent label warnings on hazardous household chemical products.

This act required that these products be labeled with information about potential hazards and instructions for safe handling to protect consumers.

Note that neither the FHSA nor the regulations issued require animal testing to determine whether a hazard exists. Under the FHSA animal testing is one possible option that can be used to determine the biological response and appropriate cautionary labeling.